The approach depends on the specific ground raised.
For likelihood of confusion: argue that the marks are not confusingly similar based on their visual, phonetic, and conceptual differences; demonstrate that the goods and services are sufficiently different; narrow the goods and services list to remove the overlapping area; or obtain a consent agreement from the owner of the cited mark.
For descriptiveness: argue that the mark is suggestive rather than descriptive, or submit evidence of acquired distinctiveness through long and exclusive commercial use. Amending the application to add a distinctive visual element may also help in some cases.
For other substantive grounds: the available options depend on the specific refusal. Some (such as a living person's name) can be resolved by submitting consent; others (such as a flag inclusion) may require removing the prohibited element from the mark.
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